Orthopedic prevention of asymmetry in unilateral temporomandibular joint arthritisStoustrup P, Küseler A, Kristensen KD, Herlin T, Pedersen TK. Orthopaedic splint treatment can reduce mandibular asymmetry caused by unilateral temporomandibular involvement in juvenile idiopathic arthritis. Eur J Orthod 2013;35:191-8Between 20% and 70% of patients with juvenile idiopathic arthritis demonstrate involvement of the temporomandibular joint. Among these, 40% to 50% experience unilateral temporomandibular joint involvement. The purpose of this study was to evaluate the effects of an orthopedic splint in mitigating the effects of unilateral juvenile idiopathic arthritis on mandibular growth and dentoalvelolar development. Twenty-two patients were treated with a distraction splint. This appliance is an acrylic splint that covers the occlusal surfaces of the mandibular teeth; the posterior height on the arthritic side is gradually increased to prevent eruption of the mandibular first molar while allowing eruption of the maxillary first molar. The treatment objectives were to correct the cant of the occlusal plane, gradually unload the joint, and guide the mandible into the normal anterior rotational growth pattern. Condylar height, ramus height, and total mandibular vertical height were measured on panoramic views constructed from cone-beam computed tomography images before and after treatment. A ratio between the affected and unaffected sides was calculated for each variable of interest to measure mandibular asymmetry. The results showed that the distraction splint decreased mandibular asymmetry for ramus height and total vertical mandibular height. Mandibular growth rates on the affected and unaffected sides were comparable in most patients. Although the unaffected side was used as a control, both the possible subsequent juvenile idiopathic arthritis of the normal temporomandibular joint and the effects of appliance therapy on dentoalveolar development on this side make the suitability of this internal control questionable. Because no control group was used, it is difficult to conclude whether or which of the outcomes were due to treatment. Nevertheless, the findings on the possible effects of this splint therapy and future studies with appropriate controls could provide valuable information on the efficacy of splint therapy in the management of this complex disorder.Reviewed by Mona BajestanNickel-free titanium-niobium material for orthodontic wiresArciniegas M, Manero JM, Espinar E, Llamas JM, Barrera JM, Gil FJ. New Ni-free superelastic alloy for orthodontic applications. Mater Sci Eng C Mater Biol Appl 2013;33:3325-8The low magnitude and continuous forces generated by superelastic nickel-titanium wires are optimal for orthodontic tooth movement. However, nickel-containing wires can cause contact dermatitis in patients with a nickel allergy. The authors of this study evaluated the superelasticity, corrosion resistance, and cytotoxicity of Ti19.1Nb8.8Zr, a new nickel-free titanium alloy that might be suitable for orthodontic applications. Phase transition and superelasticity were measured by calorimetry and by subjecting wire specimens to 150 load-unload cycles in artificial saliva at 37°C. Corrosion of the titanium alloy with specific measurements of open circuit potential, corrosion potential, and corrosion current density were compared with 6 commonly used nickel-titanium orthodontic archwires. The cytotoxicity of the titanium alloy was measured by immersing it and the controls in DMEM media at 37°C, followed by culturing of MG63 cells in this media and counting live cells. The results of the calorimetry tests showed reversible austenitic-martensitic phase transformations with martensite start-finish at 45°C to 14.8°C, and austenite start-finish at 46°C to 87°C. Repeated load and unload cycles indicated typical superelastic behavior in the titanium alloy with a mechanical phase transformation plateau from 0.5 to 8 mm of deflection. After 150 cycles, there was approximately 0.2 mm of residual elongation of the wire after deflection. The nickel-free archwire had the best resistance to corrosion among all the wires investigated. The titanium-alloy wires showed favorable cytotoxicity values, with 100% of the cells remaining viable at 72 hours; this was not significantly different relative to the controls. The nickel-free Ti19.1Nb8.8Zr alloy demonstrates superelastic behavior, better corrosion resistance compared with common nickel-titanium wires, and excellent biocompatibility. Since the authors used a 2.5-mm diameter wire, which is substantially larger than those used in orthodontic practices, further investigations are recommended with wire sizes more typically used for orthodontic treatment to derive clinically relevant information.Reviewed by Adam DonnellAllergic rhinitis and malocclusionLuzzi V, Ierardo G, Viscogliosi A, Fabbrizi M, Consoli G, Vozza I, et al. Allergic rhinitis as a possible risk factor for malocclusion: a case-control study in children. Int J Paediatr Dent 2013;23:274-8Chronic mouth breathing caused by airway obstruction has been theorized to produce postural changes that lead to dental or skeletal malocclusions. The authors of this case-control study recruited 275 Italian primary schoolchildren (ages, 5-9 years) to investigate the possible link between allergic rhinitis and malocclusion. The study group consisted of 125 children with malocclusion; they were compared with a control group of 150 children without malocclusion using clinical examinations, lateral cephalometric radiographs, and dental casts. Mouth breathing was determined based on lip incompetence, dry lips, and fogging on the lower side of a double-faced mirror. Airway obstruction from allergic rhinitis was determined from a questionnaire completed by the children's parents. The authors found both the prevalence of allergic rhinitis (59% vs 13%) and the severity of allergic rhinitis (multiple allergens, perennial rhinitis, and under pharmacologic treatment vs single allergen, seasonal rhinitis, and minimal pharmacologic treatment) to be significantly greater in the malocclusion group. The investigators also found that allergic rhinitis produced a slightly greater than 3-fold increased risk of dentoskeletal alteration, a slightly less than 3-fold increased risk of posterior crossbite, and a 2-fold greater risk of increased overjet. There was no significant difference in anterior open bite between the 2 groups. Based on their results, the authors concluded that allergic rhinitis should be considered a risk factor for developing a malocclusion and that orthodontic examination of children affected by allergic rhinitis is recommended for early intervention in the development of rhinitis-associated malocclusions. Their conclusions could have been further strengthened with additional information on the timing of the onset of allergic rhinitis and the frequency of pharmacologic treatment in the mouth-breathing groups.Reviewed by John DuRusselWidth and length of enamel microcracks after debondingDumbryte I, Linkeviciene L, Malinauskas M, Linkevicius T, Peciuliene V, Tikuisis K. Evaluation of enamel micro-cracks characteristics after removal of metal brackets in adult patients. Eur J Orthod 2013;35:317-22Enamel microcracks have been shown to predispose teeth to staining or plaque accumulation. As more adults—who are more prone to enamel microcracks—seek orthodontic treatment, procedures that contribute to this process take on increased clinical relevance. The purpose of this in-vitro study was to compare the location, length, and width of enamel microcracks in adult teeth before bonding and after the removal of metal brackets. Forty-five extracted teeth with intact buccal enamel were collected from middle-aged adults with no previous orthodontic treatment. The teeth were analyzed using scanning electron microscopy and divided into 3 groups: (1) teeth with existing enamel microcracks, (2) teeth without enamel microcracks, and (3) an unbonded control group used to study the effects of dehydration. After bonding, followed by bracket and residual adhesive removal, scanning electron microscopy was used to reevaluate the enamel surfaces of each tooth. The results showed that 40% of the bonded teeth developed new microcracks. Also, although there was no significant increase in the mean length of the microcracks, there was a significant increase in their mean width in the cervical third of the crown. The limitations of the study include the fact that debonding forces were not measured or standardized, and that the effects of debonding in vitro might not fully simulate the effects of debonding in a patient. Despite these limitations, the results reaffirm the importance for clinicians to pay special attention during debonding procedures, especially in the cervical third of the crown. It would be interesting to compare these results with those of a similar study of ceramic brackets to give patients more information regarding their treatment options.Reviewed by Carmen GarciaCone-beam computed tomography evaluation of alveolar bone after rapid maxillary expansionBaysal A, Uysal T, Veli I, Ozer T, Karadede I, Hekimoglu S. Evaluation of alveolar bone loss following rapid maxillary expansion using cone-beam computed tomography. Korean J Orthod 2013;43:83-95Rapid maxillary expansion (RME) is a common orthodontic procedure used for correction of maxillary transverse discrepancies and arch-length deficiencies. The authors of this study used cone-beam computed tomography to evaluate the effects of RME on cortical bone thickness, alveolar bone height, and the incidence of dehiscence and fenestration after a 6-month follow-up period. Cone-beam computed tomography images were taken of 20 subjects (9 boys: mean age, 13.97 ± 1.17 years; 11 girls: mean age, 13.53 ± 2.12 years) before and after RME. Ten additional subjects had cone-beam computed tomography images taken at a 6-month follow up appointment. Buccal alveolar height, buccal cortical bone thickness, and palatal cortical bone thickness of the maxillary canines, first and second premolars, and first molars were analyzed. Decreases in the buccal cortical bone thickness and palatal cortical bone thickness were observed for the investigated teeth after RME and at the 6-month follow up. Vertical alveolar height measured as buccal alveolar height decreased immediately after the expansion period and remained unchanged at the 6-month follow up. In general, the incidence of dehiscence was greater after treatment and at the 6-month follow-up than before RME. Since the thickness and the height of the buccal alveolar bone decreased and dehiscence formation increased, the authors concluded that RME might have detrimental effects on the supporting alveolar bone. Although the study provides important information of possible consequences of RME on the integrity of alveolar bone because measurements in 3-dimensional–rendered projections are not accurate and partial volume averaging artifacts and tooth rotations were not taken into account, caution should be exercised in interpreting the findings of this study.Reviewed by Elliot SapersteinBucally displaced canines and facial characteristicsMucedero M, Ricchiuti MR, Cozza P, Baccetti T. Prevalence rate and dentoskeletal features associated with buccally displaced maxillary canines. Eur J Orthod 2013;35:305-9Buccally displaced canines (BDCs) have long been related to insufficient arch length in the maxilla, but they have not been correlated to measurements in the skeletal complex. The authors of this study analyzed the prevalence and distribution of BDCs in a large untreated population and investigated the association of BDCs with sagittal, vertical, and transverse skeletal relationships, as well as maxillary dental crowding. The parent sample included 1852 subjects from the Department of Orthodontics of the University of Rome “Tor Vergata.” The sample was divided randomly into 2 groups. The control group, comprising the first 252 subjects, was used for calculation of the reference prevalence rates for the examined parameters. The experimental group comprised the remaining 1600 subjects. Of this group, 49 subjects had BDCs. The results showed a prevalence rate of maxillary BDCs of 3.06% in the experimental sample, with a unilateral-to-bilateral ratio of 33:16, and a male-to-female ratio of 1:1. The group with BDCs had a significantly higher prevalence of hyperdivergent subjects, a significantly smaller average maxillary intercanine width (−3.82 mm), and greater dental crowding (4.15 mm) than did the control group. The study suggests a significant association of BDCs with reduced maxillary intercanine width, maxillary crowding, and facial hyperdivergence. These characteristics can be used as indicators of the risk for developing maxillary BDCs. The authors also suggested that, as opposed to palatally displaced canines, BDCs are not predominantly under genetic control, but local dentoskeletal features act as predisposing environmental factors for BDCs upon eruption. This was generally a well-performed study that adds clarity of associated findings with maxillary BDCs. However, caution should be exercised in the investigators' attribution of maxillary BDCs to nongenetic causes.Reviewed by Brad StieperTorque expression in lingual orthodonticsSifakakis I, Pandis N, Makou M, Eliades T, Katsaros C, Bourauel C. A comparative assessment of torque generated by lingual and conventional brackets. Eur J Orthod 2013;35:375-80Among other variables, orthodontic torque expression is controlled by the dimensions of the wire, bracket placement, and the amount of third-order activation placed into the wire. The highly variable lingual tooth morphology and the different relative positions to the center of resistance between lingual and labial brackets might contribute to difficulties in lingual bracket torque control. Despite these differences, torque expression in lingual orthodontics has not been thoroughly studied. The authors of this study compared the torque expression in 4 bracket systems (0.018-in slot—Incognit lingual brackets (3M Unitek, Monrovia, Calif), STb lingual brackets (Light Lingual System; Ormco, Orange, Calif), In-Ovation L lingual brackets (DENTSPLY GAC, Islandia, NY), and conventional stainless steel brackets (Gemini Twin; 3M Unitek)—on 1 maxillary central incisor in a typodont). An orthodontic simulation system was used to sense the force-torque vectors 3 dimensionally. The greatest torque expression was observed in the Incognito and STb lingual brackets. The lowest amount of torque was found in the In-Ovation lingual and conventional labial brackets. The authors concluded that the moment of the couple produced from a rectangular wire depends more on the mode of ligation: ie, self-ligation vs conventional ligation. The authors also found that torque for lingual brackets depends more on loading than on unloading moments. These results are based on moments generated on 1 typodont tooth, with a limited sample size, and the torque activation of the wire was performed by 1 investigator. Future research to determine torque expression in a segment of teeth in a more realistic environment with a larger sample size and calibrated wire activations will provide further useful and clinically relevant information.Reviewed by Vina Zinn Orthopedic prevention of asymmetry in unilateral temporomandibular joint arthritisStoustrup P, Küseler A, Kristensen KD, Herlin T, Pedersen TK. Orthopaedic splint treatment can reduce mandibular asymmetry caused by unilateral temporomandibular involvement in juvenile idiopathic arthritis. Eur J Orthod 2013;35:191-8Between 20% and 70% of patients with juvenile idiopathic arthritis demonstrate involvement of the temporomandibular joint. Among these, 40% to 50% experience unilateral temporomandibular joint involvement. The purpose of this study was to evaluate the effects of an orthopedic splint in mitigating the effects of unilateral juvenile idiopathic arthritis on mandibular growth and dentoalvelolar development. Twenty-two patients were treated with a distraction splint. This appliance is an acrylic splint that covers the occlusal surfaces of the mandibular teeth; the posterior height on the arthritic side is gradually increased to prevent eruption of the mandibular first molar while allowing eruption of the maxillary first molar. The treatment objectives were to correct the cant of the occlusal plane, gradually unload the joint, and guide the mandible into the normal anterior rotational growth pattern. Condylar height, ramus height, and total mandibular vertical height were measured on panoramic views constructed from cone-beam computed tomography images before and after treatment. A ratio between the affected and unaffected sides was calculated for each variable of interest to measure mandibular asymmetry. The results showed that the distraction splint decreased mandibular asymmetry for ramus height and total vertical mandibular height. Mandibular growth rates on the affected and unaffected sides were comparable in most patients. Although the unaffected side was used as a control, both the possible subsequent juvenile idiopathic arthritis of the normal temporomandibular joint and the effects of appliance therapy on dentoalveolar development on this side make the suitability of this internal control questionable. Because no control group was used, it is difficult to conclude whether or which of the outcomes were due to treatment. Nevertheless, the findings on the possible effects of this splint therapy and future studies with appropriate controls could provide valuable information on the efficacy of splint therapy in the management of this complex disorder.Reviewed by Mona Bajestan Stoustrup P, Küseler A, Kristensen KD, Herlin T, Pedersen TK. Orthopaedic splint treatment can reduce mandibular asymmetry caused by unilateral temporomandibular involvement in juvenile idiopathic arthritis. Eur J Orthod 2013;35:191-8Between 20% and 70% of patients with juvenile idiopathic arthritis demonstrate involvement of the temporomandibular joint. Among these, 40% to 50% experience unilateral temporomandibular joint involvement. The purpose of this study was to evaluate the effects of an orthopedic splint in mitigating the effects of unilateral juvenile idiopathic arthritis on mandibular growth and dentoalvelolar development. Twenty-two patients were treated with a distraction splint. This appliance is an acrylic splint that covers the occlusal surfaces of the mandibular teeth; the posterior height on the arthritic side is gradually increased to prevent eruption of the mandibular first molar while allowing eruption of the maxillary first molar. The treatment objectives were to correct the cant of the occlusal plane, gradually unload the joint, and guide the mandible into the normal anterior rotational growth pattern. Condylar height, ramus height, and total mandibular vertical height were measured on panoramic views constructed from cone-beam computed tomography images before and after treatment. A ratio between the affected and unaffected sides was calculated for each variable of interest to measure mandibular asymmetry. The results showed that the distraction splint decreased mandibular asymmetry for ramus height and total vertical mandibular height. Mandibular growth rates on the affected and unaffected sides were comparable in most patients. Although the unaffected side was used as a control, both the possible subsequent juvenile idiopathic arthritis of the normal temporomandibular joint and the effects of appliance therapy on dentoalveolar development on this side make the suitability of this internal control questionable. Because no control group was used, it is difficult to conclude whether or which of the outcomes were due to treatment. Nevertheless, the findings on the possible effects of this splint therapy and future studies with appropriate controls could provide valuable information on the efficacy of splint therapy in the management of this complex disorder.Reviewed by Mona Bajestan Between 20% and 70% of patients with juvenile idiopathic arthritis demonstrate involvement of the temporomandibular joint. Among these, 40% to 50% experience unilateral temporomandibular joint involvement. The purpose of this study was to evaluate the effects of an orthopedic splint in mitigating the effects of unilateral juvenile idiopathic arthritis on mandibular growth and dentoalvelolar development. Twenty-two patients were treated with a distraction splint. This appliance is an acrylic splint that covers the occlusal surfaces of the mandibular teeth; the posterior height on the arthritic side is gradually increased to prevent eruption of the mandibular first molar while allowing eruption of the maxillary first molar. The treatment objectives were to correct the cant of the occlusal plane, gradually unload the joint, and guide the mandible into the normal anterior rotational growth pattern. Condylar height, ramus height, and total mandibular vertical height were measured on panoramic views constructed from cone-beam computed tomography images before and after treatment. A ratio between the affected and unaffected sides was calculated for each variable of interest to measure mandibular asymmetry. The results showed that the distraction splint decreased mandibular asymmetry for ramus height and total vertical mandibular height. Mandibular growth rates on the affected and unaffected sides were comparable in most patients. Although the unaffected side was used as a control, both the possible subsequent juvenile idiopathic arthritis of the normal temporomandibular joint and the effects of appliance therapy on dentoalveolar development on this side make the suitability of this internal control questionable. Because no control group was used, it is difficult to conclude whether or which of the outcomes were due to treatment. Nevertheless, the findings on the possible effects of this splint therapy and future studies with appropriate controls could provide valuable information on the efficacy of splint therapy in the management of this complex disorder. Reviewed by Mona Bajestan Nickel-free titanium-niobium material for orthodontic wiresArciniegas M, Manero JM, Espinar E, Llamas JM, Barrera JM, Gil FJ. New Ni-free superelastic alloy for orthodontic applications. Mater Sci Eng C Mater Biol Appl 2013;33:3325-8The low magnitude and continuous forces generated by superelastic nickel-titanium wires are optimal for orthodontic tooth movement. However, nickel-containing wires can cause contact dermatitis in patients with a nickel allergy. The authors of this study evaluated the superelasticity, corrosion resistance, and cytotoxicity of Ti19.1Nb8.8Zr, a new nickel-free titanium alloy that might be suitable for orthodontic applications. Phase transition and superelasticity were measured by calorimetry and by subjecting wire specimens to 150 load-unload cycles in artificial saliva at 37°C. Corrosion of the titanium alloy with specific measurements of open circuit potential, corrosion potential, and corrosion current density were compared with 6 commonly used nickel-titanium orthodontic archwires. The cytotoxicity of the titanium alloy was measured by immersing it and the controls in DMEM media at 37°C, followed by culturing of MG63 cells in this media and counting live cells. The results of the calorimetry tests showed reversible austenitic-martensitic phase transformations with martensite start-finish at 45°C to 14.8°C, and austenite start-finish at 46°C to 87°C. Repeated load and unload cycles indicated typical superelastic behavior in the titanium alloy with a mechanical phase transformation plateau from 0.5 to 8 mm of deflection. After 150 cycles, there was approximately 0.2 mm of residual elongation of the wire after deflection. The nickel-free archwire had the best resistance to corrosion among all the wires investigated. The titanium-alloy wires showed favorable cytotoxicity values, with 100% of the cells remaining viable at 72 hours; this was not significantly different relative to the controls. The nickel-free Ti19.1Nb8.8Zr alloy demonstrates superelastic behavior, better corrosion resistance compared with common nickel-titanium wires, and excellent biocompatibility. Since the authors used a 2.5-mm diameter wire, which is substantially larger than those used in orthodontic practices, further investigations are recommended with wire sizes more typically used for orthodontic treatment to derive clinically relevant information.Reviewed by Adam Donnell Arciniegas M, Manero JM, Espinar E, Llamas JM, Barrera JM, Gil FJ. New Ni-free superelastic alloy for orthodontic applications. Mater Sci Eng C Mater Biol Appl 2013;33:3325-8The low magnitude and continuous forces generated by superelastic nickel-titanium wires are optimal for orthodontic tooth movement. However, nickel-containing wires can cause contact dermatitis in patients with a nickel allergy. The authors of this study evaluated the superelasticity, corrosion resistance, and cytotoxicity of Ti19.1Nb8.8Zr, a new nickel-free titanium alloy that might be suitable for orthodontic applications. Phase transition and superelasticity were measured by calorimetry and by subjecting wire specimens to 150 load-unload cycles in artificial saliva at 37°C. Corrosion of the titanium alloy with specific measurements of open circuit potential, corrosion potential, and corrosion current density were compared with 6 commonly used nickel-titanium orthodontic archwires. The cytotoxicity of the titanium alloy was measured by immersing it and the controls in DMEM media at 37°C, followed by culturing of MG63 cells in this media and counting live cells. The results of the calorimetry tests showed reversible austenitic-martensitic phase transformations with martensite start-finish at 45°C to 14.8°C, and austenite start-finish at 46°C to 87°C. Repeated load and unload cycles indicated typical superelastic behavior in the titanium alloy with a mechanical phase transformation plateau from 0.5 to 8 mm of deflection. After 150 cycles, there was approximately 0.2 mm of residual elongation of the wire after deflection. The nickel-free archwire had the best resistance to corrosion among all the wires investigated. The titanium-alloy wires showed favorable cytotoxicity values, with 100% of the cells remaining viable at 72 hours; this was not significantly different relative to the controls. The nickel-free Ti19.1Nb8.8Zr alloy demonstrates superelastic behavior, better corrosion resistance compared with common nickel-titanium wires, and excellent biocompatibility. Since the authors used a 2.5-mm diameter wire, which is substantially larger than those used in orthodontic practices, further investigations are recommended with wire sizes more typically used for orthodontic treatment to derive clinically relevant information.Reviewed by Adam Donnell The low magnitude and continuous forces generated by superelastic nickel-titanium wires are optimal for orthodontic tooth movement. However, nickel-containing wires can cause contact dermatitis in patients with a nickel allergy. The authors of this study evaluated the superelasticity, corrosion resistance, and cytotoxicity of Ti19.1Nb8.8Zr, a new nickel-free titanium alloy that might be suitable for orthodontic applications. Phase transition and superelasticity were measured by calorimetry and by subjecting wire specimens to 150 load-unload cycles in artificial saliva at 37°C. Corrosion of the titanium alloy with specific measurements of open circuit potential, corrosion potential, and corrosion current density were compared with 6 commonly used nickel-titanium orthodontic archwires. The cytotoxicity of the titanium alloy was measured by immersing it and the controls in DMEM media at 37°C, followed by culturing of MG63 cells in this media and counting live cells. The results of the calorimetry tests showed reversible austenitic-martensitic phase transformations with martensite start-finish at 45°C to 14.8°C, and austenite start-finish at 46°C to 87°C. Repeated load and unload cycles indicated typical superelastic behavior in the titanium alloy with a mechanical phase transformation plateau from 0.5 to 8 mm of deflection. After 150 cycles, there was approximately 0.2 mm of residual elongation of the wire after deflection. The nickel-free archwire had the best resistance to corrosion among all the wires investigated. The titanium-alloy wires showed favorable cytotoxicity values, with 100% of the cells remaining viable at 72 hours; this was not significantly different relative to the controls. The nickel-free Ti19.1Nb8.8Zr alloy demonstrates superelastic behavior, better corrosion resistance compared with common nickel-titanium wires, and excellent biocompatibility. Since the authors used a 2.5-mm diameter wire, which is substantially larger than those used in orthodontic practices, further investigations are recommended with wire sizes more typically used for orthodontic treatment to derive clinically relevant information. Reviewed by Adam Donnell Allergic rhinitis and malocclusionLuzzi V, Ierardo G, Viscogliosi A, Fabbrizi M, Consoli G, Vozza I, et al. Allergic rhinitis as a possible risk factor for malocclusion: a case-control study in children. Int J Paediatr Dent 2013;23:274-8Chronic mouth breathing caused by airway obstruction has been theorized to produce postural changes that lead to dental or skeletal malocclusions. The authors of this case-control study recruited 275 Italian primary schoolchildren (ages, 5-9 years) to investigate the possible link between allergic rhinitis and malocclusion. The study group consisted of 125 children with malocclusion; they were compared with a control group of 150 children without malocclusion using